产品描述:
Alisol C monoacetate is a triterpenoid that has been found in Alisma orientale and has diverse biological activities.{63256,68043,68044,68045} It is active against certain antibiotic-resistant strains of S. aureus, E. faecium, E. coli, and P. aeruginosa (MICs = 2.5-5 µg/ml) but not against other antibiotic-resistant strains of S. aureus or E. coli (MICs = >256 µg/ml).{68043,68044} Alisol C monoacetate (1-10 µM) inhibits osteoclast formation induced by calcitriol (Item No. 71820) in a co-culture of primary rat osteoblasts and primary rat bone marrow cells.{68045} It reduces trabecular bone loss and serum levels of a variety of cytokines, including TNF-α, IL-6, and IL-1β, in an ovariectomized rat model of osteoporosis when administered at doses of 1 and 2 mg/kg. Alisol C monoacetate (10 and 50 mg/kg) also reduces ear edema in a mouse model of delayed-type hypersensitivity.{63256}