产品描述:
PAF C-16-d4 contains four deuterium atoms at the 7, 7', 8, and 8' positions of the hexadecyl moiety. It is intended for use as an internal standard for the quantification of PAF C-16 by GC- or LC-mass spectrometry. PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the “remodeling” and 'de novo' pathways.{939} It is a potent mediator of neutrophil migration,{1437} the production of reactive oxygen species,{367} and IL-6{2296} in human macrophages. It is a more potent mediator of platelet aggregation than PAF C-18{3786}. Pathological processes involving PAF include necrotizing enterocolitis,{5841} inflammation, asthma, and allergy.{303}