产品描述:
4-Hydroxyestradiol is a catechol estrogen and minor metabolite of estrogen.{57239,57240} 4-Hydroxyestradiol is formed from estrogen by the cytochrome P450 (CYP) isoform CYP1B1.{57240} Production of 4-hydroxyestradiol is increased in microsomes prepared from human mammary adenocarcinoma and fibroadenoma microsomes compared with microsomes prepared from non-cancerous tissues.{57239} 4-Hydroxyestradiol (25 mg/animal) induces renal tumor formation in male hamsters.{57241}