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(25S)-Δ7-Dafachronic Acid
品牌： Cayman
产品货号： 14101-500 µg
规格： 500 µg

报价：
折后价：

数量： - +
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  • 产品名称:
    (25S)-Δ7-Dafachronic Acid
  • 别名:
    (25S)-Δ7-DA|UPF-1404
  • 产品描述:
    During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival.{22033,22027} DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans.{22030,22029,22015} DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. (25S)-Δ7-Dafachronic acid is a sterol-derived hormone that acts as a ligand of DAF-12 with an EC50 value of 23 nM.{22030,22032,22014,22028} At 50 nM, (25S)-Δ7-Dafachronic acid inhibits the dauer-promoting activity of DAF-12, blocking the formation of infective larvae in several parasitic nematodes in favor of reproductive maturation to adults.{22031,22033} Thus, selective ligand modulators of DAF-12 are a potential therapeutic approach to stop larvae progression during parasitic infection.{22027}
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  • 阳性对照:
  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    414.6
  • 产品形式:
    A crystalline solid
  • 存储溶液:
  • 有效期:
    730
  • 产地:
    美国
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  • 纯度:
    ≥95%
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  • CAS号:
    949004-12-0
  • 分子式:
    C27H42O3
  • 溶解度:
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