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N-glycolyl-Ganglioside GM3 (ammonium salt)
品牌： Cayman
产品货号： 33263
规格： 500 µg

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数量： - +
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  • 产品名称:
    N-glycolyl-Ganglioside GM3 (ammonium salt)
  • 别名:
    GM3-Neugc|NeuGc-GM3|NGcGM3|N-glycolyl-GM3|N-glycolyl-Monosialoganglioside GM3|N-Glycolylneuraminyllactosylceramide
  • 产品描述:
    N-glycolyl-Ganglioside GM3 (NeuGc-GM3) is a form of ganglioside GM3 that contains an N-glycolylated sialic acid (NeuGc). It is not biosynthesized in humans under baseline conditions due to a mutation in CMP-Neu5Ac hydroxylase (CMAH), which converts N-acetyl sialic acid to N-glycolyl sialic acid, but NeuGc can be taken up by human cells via the diet and incorporated into glycolipids, such as ganglioside GM3.{54575,60205} NeuGc-GM3 impairs differentiation and maturation of dendritic cells in vitro and reduces CD4 expression in non-activated T cells.{54575,60206} It increases the number of lung tumor nodules formed in a murine Lewis lung carcinoma model.{60207} It is found in a variety of human cancers, including breast and lung cancers, as well as pediatric cancers.{54575} Levels of NeuGc-GM3 are negatively correlated with the number of mature dendritic cells in patient-derived non-small cell lung cancer (NSCLC) tumor tissue.{60208} Anti-NeuGc-GM3 antibodies, able to destroy tumor cells in vitro, have been found in individuals without cancer but not in patients with NSCLC.{54575,60209} This product contains ganglioside GM3 molecular species with primarily C22:0, C23:0, and C24:0 fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1553]
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  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    1284.7
  • 产品形式:
    A solid
  • 存储溶液:
  • 有效期:
    1460
  • 产地:
    美国
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  • 纯度:
    ≥98%
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  • CAS号:
    69345-49-9
  • 分子式:
    C64H117N2O22 • NH4 (for tricosanoyl)
  • 溶解度:
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