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Nat-20(S)-yne
品牌: Cayman
产品货号: 9001369-25 mg
规格: 25 mg

报价:
折后价:

数量: - +
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
  • 产品名称:
    Nat-20(S)-yne
  • 别名:
    Click Tag™ Nat-20(S)-yne
  • 产品描述:
    Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors.{21774} 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which binds SMO and activates hedgehog signaling (EC50 = 3 μM), and this activation is selective for the nat-20(S)-OHC enantiomer.{21991} Nat-20(S)-OHC synergizes with the SMO agonist SAG, suggesting an allosteric effect.{21991} Nat-20(S)-yne is a form of nat-20(S)-OHC with a terminal alkyne group, which can be used in linking reactions known as click chemistry. Click chemistry involves highly dependable and specific azide-alkyne bioconjugation reactions and can be used to capture or immobilize bioactive molecules.{17990,17992} Thus, nat-20(S)-yne has been conjugated with magnetic beads to demonstrate that nat-20(S)-OHC directly binds SMO.{21991}
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  • 阳性对照:
  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    370.6
  • 产品形式:
    A crystalline solid
  • 存储溶液:
  • 有效期:
    730
  • 产地:
    美国
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  • 纯度:
    ≥90%
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  • CAS号:
    1397692-46-4
  • 分子式:
    C25H38O2
  • 溶解度:
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