产品描述:
Estrone-d2 is intended for use as an internal standard for the quantification of estrone (Item No. 10006485) by GC- or LC-MS. Estrone is one of the three naturally occurring estrogens, the others being estradiol (Item Nos. ISO60155 | 10006315) and estriol (Item No. 10006484).{9611} Estrone is synthesized from androstenedione (Item No. 9001311) by the aromatase enzyme system in the ovaries and placenta, and is also synthesized from estradiol by 17-hydroxy steroid dehydrogenase in the liver.{9611,8343} Serum concentrations of estrone in premenopausal women fluctuate according to the menstrual cycle and becomes the most predominant estrogen in postmenopausal women.{9611} The binding affinities of estrone to the estrogen receptors α and β are approximately 60% and 37% relative to estradiol.{9611}