产品描述:
Ginsenoside Rb1 is a triterpene saponin that has been found in P. ginseng and has diverse biological activities.{24876,24875,67161,67162,67163} It decreases apoptosis and increases in protein kinase A (PKA), PKC, caspase-3, and caspase-9 levels induced by isoproterenol (Item No. 15592) in H9c2 rat cardiomyocytes when used at a concentration of 100 µM.{24876} Ginsenoside Rb1 (1 µM) inhibits glucose-induced cytotoxicity and production of reactive oxygen species (ROS) in primary rat hippocampal neurons.{24875} It inhibits LPS-induced activation of IL-1 receptor-associated kinase 1 (IRAK1), IΚΚβ, NF-κB, as well as the MAP kinases ERK, JNK, and p38, in mouse peritoneal lavage fluid when used at a concentration of 100 µM.{67162} Ginsenoside Rb1 (10 mg/kg for 30 days) increases hippocampus nestin and glial fibrillary acidic protein (GFAP) levels, markers of neural stem cells and astrocytes respectively, in a rat model of Alzheimer’s disease induced by amyloid-β (1-40) (Aβ40).{67161} It decreases high-fat diet-induced increases in liver weight, hepatic triglyceride accumulation, serum fasting glucose levels, and serum LDL levels in a mouse model of obesity when administered at a dose of 200 mg/kg per day.{67163}