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(±)-2-Methyl Arachidonoyl-2'-Fluoroethylamide
品牌： Cayman
产品货号： 90055-50 mg
规格： 50 mg

报价：
折后价：

数量： - +
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  • 产品名称:
    (±)-2-Methyl Arachidonoyl-2'-Fluoroethylamide
  • 别名:
    2-methyl-2'-fluoro AEA|2-Methyl-2'-fluoro Anandamide|O-689
  • 产品描述:
    (±)-2-Methyl arachidonoyl-2'-fluoroethylamide (2-Methyl-2'-fluoro AEA) is an analog of anandamide (AEA) in which the alcohol of the ethanolamide group has been removed and replaced with a fluorine atom. This substitution confers considerably increased binding affinity for the CB1 receptor (Ki = 5.7 nM in rat brain). It also confers additional selectivity, in that binding to CB2 is decreased relative to AEA.{7422} However, the in vivo activity of 2-fluoro AEA is enhanced much less than the binding affinity, because the analog remains a good substrate for FAAH and is rapidly hydrolyzed by this enzyme. 2-Methyl-2'-fluoro AEA is further modified by the addition of an α-methyl group at the C-2 position of arachidonic acid. This substitution confers enhanced metabolic stability. 2-Methyl-2'-fluoro AEA can fully substitute for Δ9-THC in animal self-administration tests, whereas AEA and 2-fluoro AEA cannot.{8152}
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  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    363.6
  • 产品形式:
    A solution in ethanol
  • 存储溶液:
  • 有效期:
    730
  • 产地:
    美国
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  • 纯度:
    ≥95%
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  • CAS号:
    166100-39-6
  • 分子式:
    C23H38FNO
  • 溶解度:
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