产品描述:
Monascin is an azaphilonoid pigment that has been found in the fungus Monascus and has diverse biological activities.{72204,72203,72205} It induces peroxisome proliferator-activated receptor α (PPARα) activity in a coactivator assay (IC50 = 2,038 nM) and inhibits oleic acid-induced fatty acid uptake, lipogenesis, and fatty acid oxidation in FL83B mouse hepatocytes.{72204} In vivo, monascin reduces hepatic IL-6, TNF-α, and TGF-β levels, plasma levels of total cholesterol, triglycerides, free fatty acids, and alanine transaminase (ALT), and hepatic macrovesicular steatosis in a mouse model of high-fat diet-induced non-alcoholic steatohepatitis (NASH). Monascin reduces the number of papillomas per mouse and the number of mice with papillomas in a mouse model of two-stage carcinogenesis induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) and UVB or peroxynitrite when administered in the drinking water at a concentration of 0.0025%.{72203} It also reduces serum insulin, triglyceride, total cholesterol, and HDL concentrations in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104).{72205}