产品描述:
8S(9R)-EET is an oxylipin and a metabolite of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607).{313} It is formed via oxidation of arachidonic acid by the cytochrome P450 (CYP) isoforms CYP1A1, CYP1A2, CYP2B1, and CYP2B2. 8S(9R)-EET induces relaxation of precontracted isolated dog epicardial arterioles (EC50 = 121 pM).{52399} Intrarenal infusion of 8S(9R)-EET (0.5, 1, or 2 µg/kg per minute) induces glomerular vasoconstriction and reduces the glomerular filtration rate in rats.{1111}