产品描述:
L-Alanosine is an antibiotic derived from bacterium S. alanosinicus with antineoplastic activity in cells deficient in methylthioadenosine phosphorylase (MTAP) (mean IC50 = 4.8 μM and 10 μM in T-ALL and CAK-1 cells, respectively).{34433,34434} L-Alanosine inhibits adenylosuccinate synthetase to disrupt de novo purine biosynthesis, inhibiting cellular metabolism in MTAP-deficient tumor cells.{34435,34436,34437}