产品描述:
Phenprocoumon is an anticoagulant and vitamin K antagonist.{61088,61089} It inhibits the activity of wild-type vitamin K epoxide reductase (VKOR; IC50 = 4.2 nM), as well as a variety of mutant VKORs (IC50s = 5.1-835 nM), in cell-based reporter assays.{61088} Phenprocoumon inhibits prothrombin complex synthesis in rats in a dose-dependent manner.{61089} Formulations containing phenprocoumon have previously been used in the prevention and treatment of thromboembolic disorders.