产品描述:
Entecavir is an antiviral nucleoside analog of 2'-deoxyguanosine (Item No. 9002864) and inhibitor of hepatitis B virus (HBV) reverse transcriptase (IC50 = 0.5 nM).{22164,59703} It undergoes phosphorylation by cellular kinases to its active form, entecavir triphosphate.{53861,59703} Entecavir reduces virion DNA in the culture supernatant of HepG2 2.2.15 cells infected with hepatitis B virus (HBV; EC50 = 3.75 nM).{22164} It reduces serum and hepatic levels of viral DNA in a duckling model of HBV infection when administered at a dose of 1 mg/kg.{22166} Formulations containing entecavir have been used in the treatment of chronic HBV infection.