产品描述:
Aliskiren is a nonpeptide inhibitor of renin (IC50 = 0.6 nM for the human enzyme).{31535} Aliskiren (10 and 30 mg/kg per day) reduces blood pressure and prevents albuminuria in renin-overexpressing TG(mRen-2)27 rats in a model of streptozotocin-induced diabetes.{61205} It also reduces cardiac hypertrophy and fibrosis induced by heart pressure overload in mice.{61206} Formulations containing aliskiren have been used in the treatment of hypertension.