产品描述:
NE 100 is a potent antagonist of sigma-1 (σ1) receptors (IC50 = 4.16 nM).{33464,33467,33468} It only weakly antagonizes dopamine, serotonin, and PCP receptors, but may indirectly alter receptor activity through its effects on σ1.{33464,33467,33468} NE 100 is commonly used to study the role of σ1 receptor signaling in cells or animals.{33465,33466}