产品描述:
Adaptaquin is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2; IC50 = 2 micromolar).{43311} It stabilizes HIF-1α protein and induces expression of the HIF-1-regulated genes EPO and VEGF in SH-SY5Y human neuroblastoma cells. Adaptaquin protects against cell death induced by glutathione depletion in rat primary cortical neurons (IC50 = 0.25 μM) and reduces glutamate-induced cell death in HT-22 cells.{43311,32914} In vivo, adaptaquin (30 mg/kg) increases pellet retrieval in the single-pellet reaching task in a rat autologous striatal blood infusion model of intracerebral hemmorhage and normalizes preference for ipsilateral turns in a mouse model of striatal hemorrhage.{31664}