产品描述:
Acivicin is a glutamine analog that irreversibly inhibits glutamine-dependent amidotransferases involved in nucleotide and amino acid biosynthesis (Kis = 10 and 560 μM for anthranilate synthase and glutamate synthase, respectively).{21903,21899} It also reversibly inhibits γ-glutamyl transpeptidase.{21902,21901} Acividin has been used to elucidate aspects of glutathione metabolism and has known anti-tumorigenic activity.{21899,21898,21900,21897}