产品描述:
(+)-Aphidicolin is a natural tetracyclic diterpene first isolated from the fungus C. aphidicola and shown to have antiviral activity against herpes simplex.{22496} In eukaryotic cells, it is a cell-permeable, reversible inhibitor of DNA replication, specifically blocking the activity of DNA polymerases α, δ, and ε when used at low micromolar levels.{22501,22499,22497} Aphidicolin can be used, at 3 μM, to arrest cells in G1/S phase or to increase gene amplification frequency.{22498,22502}