产品描述:
CPTH6 is a thiazole derivative that inhibits the lysine acetyltransferase activity of Gcn5 and pCAF but not p300 or CBP.{33399} It blocks the acetylation of H3/H4 histones and α-tubulin in several leukemia cell lines.{33399} CPTH6 reduces cell viability, arresting cell cycling in the G0/G1 phase and inducing apoptosis.{33399} It impairs autophagy in a variety of tumor cell lines, at least in part by altering ATG7-mediated elongation of autophagosomal membranes.{33398}