产品描述:
Fumonisin B1 (FB1) is a mycotoxin that has been found in F. moniliforme.{1632} It inhibits ceramide synthase (IC50 = 0.1 µM for the rat liver enzyme).{5545} FB1 induces DNA fragmentation and apoptosis in CV-1 cells when used at concentrations of 5 and 25 µM, respectively.{10371} It is cytotoxic to primary rat hepatocytes and induces hepatocyte nodule formation, a marker of cancer initiation, in rats when administered at a dose of 500 mg/kg for 21 days.{61109} It has been detected in corn and corn-based foods and livestock feeds.{61110}