产品描述:
BRD6688 is an HDAC inhibitor with IC50 values of 21 nM, 100 nM, and 11.48 µM for HDAC1, 2, and 3, respectively.{32059} It possesses preferential binding kinetics with six-fold extended half-life on HDAC2 compared to HDAC1 (381 min versus 65 min).{32059} BRD6688 crosses the blood brain barrier and has been shown to rescue the memory defects associated with p25 induced neurodegeneration in contextual fear conditioning in a CK-p25 mouse model of neurodegeneration.{32059}