产品描述:
CID-2858522 is an 2-amino benzimidazole that inhibits activation of the NF-κB pathway induced by the PKC activator PMA with an IC50 value of 0.07 μM.{24527} It has been shown to inhibit IL-8 production induced by PKC activators in HEK293 cells (IC50 ≤ 0.1 μM), attenuate CD3/CD28 and PMA/ionomycin-induced production of IL-2 by Jurkat T cells (IC50 ≤ 5 μM), and prevent anti-IgM-stimulated proliferation of mouse B-lymphocytes (IC50 = ∼2 μM).{24527} CID-2858522 does not, however, inhibit the NF-κB pathway activated by TNF-α.{24527}