产品描述:
Clofarabine is a nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase-α (IC50s = 65 and 3.9 nM, respectively) and is cytotoxic to K562 myelogenous leukemia cells (IC50 = 5 nM).{22561} It induces apoptosis in primary chronic lymphocytic leukemia cells by directly altering mitochondrial transmembrane potential.{22560} Clofarabine demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.{22558,22559,22562}