产品描述:
AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) that specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of 2-hydroxyglutarate.{32361} AG-120 may induce cellular differentiation as well as inhibit proliferation in IDH1-expressing tumor cells.{32361}