产品描述:
Chrysomycin B is an antibiotic isolated from a strain of Streptomyces.{22201} It differs from its analog chrysomycin A (Item No. 14188){22203,22199} by having a methyl, rather than vinyl, group in the 8-position of the chromophore. Like its analog, chrysomycin B suppresses the growth of transplantable tumors in mice, an effect that may be related to its ability to bind DNA.{22199,22204,22198} It also causes DNA damage in the human lung adenocarcinoma A549 cell line and inhibits topoisomerase II.{22198} Chrysomycin B is structurally very similar to gilvocarcin V, which promotes DNA cross-linking with histone 3 and GRP78 when photoactivated by near-UV light.{22200}