产品描述:
Luotonin A is an alkaloid originally isolated from a plant used in traditional Chinese medicine.{22184} It inhibits the growth of mouse leukemia P388 cells (IC50 = 1.8 μg/ml).{22184} Luotonin A is structurally similar to the alkaloid camptothecin (Item No. 11694) and, like camptothecin, it binds to and stabilizes the topoisomerase I-DNA binary complex, leading to DNA breakage and cell death (IC50 = 5.07-12.6 μM).{25352} Also like camptothecin, luotonin A forms non-covalent complexes with double-stranded DNA in the minor groove and this association can be followed by native fluorescence associated with the aromatic and heterocyclic ring structure.{25350} Luotonin A also selectively inhibits the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 (IC50 = ~6 μM for each) in human liver microsomes.{25351}