产品描述:
CeMMEC1 is an N-methylisoquinolinone that inhibits the second bromodomain of TAF1 (Kd = 1.8 µM; IC50 = 0.9 µM).{31547} It does not bind to either the first or second bromodomain of BRD4.{31547} This compound synergizes with (+)-JQ1 (Item No. 11187) to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells.{31547}