产品描述:
Chebulinic acid is an ellagitannin that has been found in T. chebula and has diverse biological activities.{57331,57332,60057,57333,57334} It is an inhibitor of protein tyrosine phosphatase non-receptor 9 (PTPN9) and PTPN11 (IC50s = 34 and 37 nM, respectively).{57332} Chebulinic acid (5 µM) increases glucose uptake in 3T3-L1 preadipocytes. It induces apoptosis of HL-60 and NB4 acute promyelocytic leukemia (APL), but not K562 chronic myelogenous leukemia (CML), cells (IC50s = 7.5, 5, and >60 µM, respectively).{57331} Chebulinic acid (25 µM) reduces the production of reactive oxygen species (ROS) induced by glyceraldehyde-related advanced glycation end products (glycer-AGEs) in human umbilical vein endothelial cells (HUVECs) and reduces glutamate-induced ROS production and cell death in HT22 mouse hippocampal cells.{60057,57333} It inhibits H+/K+-ATPase activity (IC50 = 65.01 µg/ml) and reduces free and total gastric acidity, as well as increases gastric mucin secretion, in various rat models of gastric ulcer.{57334}