产品描述:
Lovastatin-d9 is intended for use as an internal standard for the quantification of lovastatin (Item No. 10010338) by GC- or LC-MS. Lovastatin is a fungal metabolite that has been found in A. terreus and an inhibitor of HMG-CoA reductase (Ki = 1.4 nM).{15081,15251} It is also a prodrug form of the HMG-CoA reductase inhibitor lovastatin hydroxy acid (Item No. 10010339).{15251} Lovastatin (8 mg/kg per day) reduces plasma cholesterol levels in dogs. It suppresses TNF-induced NF-κB activation (IC50 = ~15 µM) and potentiates apoptosis in human myeloid leukemia cells.{15363} Lovastatin also increases cellular lipid peroxidation and decreases glutathione peroxidase 4 (GPX4) levels in cancer cells.{43393} Formulations containing lovastatin have been used in the treatment of hypercholesterolemia.