产品描述:
Chetomin is a natural product isolated from Chaetomium species which has antibacterial and antifungal properties.{22491} It is a small molecule inhibitor of hypoxia-inducible factor (HIF) signaling, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.{22490} Chetomin effectively attenuates the HIF pathway both in cells and in vivo, in mice.{22490} It inhibits HIF-dependant signaling, cell growth, and tumor growth in cancer cells and xenografts.{22490,22489}