产品描述:
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species.{22577,22591} PJ-34 is an inhibitor of PARPs which can be used in cells or in animals.{22593,22588,22592} It binds and inhibits the PARP tankyrase1 (IC50 = 1 μM).{22590} PJ-34 also inhibits matrix metalloproteinase-2 when used at higher concentrations (IC50 = 56 μM).{20001}