产品描述:
Nelarabine is a purine nucleoside analog that is used as a cytotoxic agent in hematological malignancies.{23725} Nelarabine is converted into arabinosyl-guanine (ara-G) in the blood, and ara-G is selectively accumulated in T cells and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into DNA.{32257,32256} This leads to DNA breaks, increased expression of Fas ligand, and apoptosis.{23725,32256} Ara-G is accumulated most effectively by acute lymphoid leukemia and chronic myeloid leukemia blasts.{23725}