产品描述:
Emtricitabine S-oxide is a potential impurity found in commercial preparations of emtricitabine.{47152} Emtricitabine (Item No. 16879) is a nucleoside analog and an inhibitor of HIV-1 and hepatitis B reverse transcriptase with antiviral activity.{53352} It inhibits replication of HIV-1 (EC50s = 10-20 nM) and hepatitis B (EC50s = 10-40 nM) in various cell lines.{27859} Emtricitabine inhibits duck hepatitis B viral DNA synthesis when administered pre- and post-viral inoculation in primary duck hepatocytes.{53353} In vivo, emtricitabine (3-30 mg/kg) reduces viremia and hepatic woodchuck hepatitis virus (WHV) replication in a dose-dependent manner in a woodchuck model of chronic WHV infection.{53354} Formulations containing emtricitabine have been used in the treatment of HIV infection.