产品描述:
MSDC-0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities.{9838} It inactivates the mitochondrial pyruvate carrier (MPC; IC50 = 1.2 µM) without affecting peroxisome proliferator-activated receptor γ (PPARγ; IC50 = 31.65 µM) in vitro.{48099} MSDC-0160 enhances the rate of insulin-stimulated lipogenesis in 3T3-L1 adipocytes in a dose-dependent manner.{9838} Dietary administration of MSDC-0160 (100 mg/kg) lowers blood glucose levels in obese, hyperglycemic, hyperinsulinemic, and insulin-resistant KKAγ mice. MSDC-0160 prevents neurodegeneration in a C. elegans model of Parkinson's disease, an effect that is blocked by knockdown of the mammalian target of rapamycin (mTOR).{48099} It also prevents overactivation of mTOR in the MPTP-induced and engrailed heterozygous (En+/-) mouse models of Parkinson's disease.