产品描述:
Bumetanide is an inhibitor of Na-K-2Cl cotransporter 1 (NKCC1; IC50 = 0.68 µM).{60442} It is selective for NKCC1 over NKCC2 (IC50 = 4 µM). Bumetanide is an agonist of G protein-coupled receptor 35 (GPR35; EC50 = 10 µM).{60443} It also inhibits various carbonic anhydrases.{23242} Bumetanide (0.1 mg/kg) increases urine flow and sodium and potassium excretion, as well as decreases sodium reabsorption, in anesthetized dogs.{60444} It reduces brain edema and infarct size in a rat model of stroke induced by permanent middle cerebral artery occlusion (MCAO) when administered at doses ranging from 7.6 to 30.4 mg/kg.{60445} Formulations containing bumetanide have been used in the treatment of edema associated with congestive heart failure and hepatic and renal diseases.