产品描述:
Human sirtuin 2 (SIRT2) is a NAD+-dependent protein deacetylase with diverse targets, including α-tubulin, phosphoenolpyruvate carboxykinase, and forkhead box protein O1. JFD00244 is an inhibitor of SIRT2 (IC50= 56.7 µM).{23576} At 5 µM, JFD00244 induces granulocytic differentiation in the acute promyelocytic leukemia cell line NB4.{23577}