产品描述:
Carnosol is a phenol that has been found in rosemary (R. officinalis) and has diverse biological activities.{8781,6842,53877,6784} It decreases nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at concentrations ranging from 6 to 25 µM.{8781} Carnosol scavenges peroxyl and hydroxyl radicals and inhibits lipid peroxidation in cell-free assays.{6842} It inhibits 5-lipoxygenase (5-LO; IC50 = 0.1 µM for the recombinant human enzyme) and the synthesis of leukotrienes in human polymorphonuclear leukocytes (PMNs; IC50 = 7 µM).{53877} In vivo, carnosol (200 mg/kg) reduces mammary DNA adduct formation and tumorigenesis in a rat model of DMBA-induced mammary tumorigenesis.{6784}