产品描述:
Linarin is a flavonoid glycoside that has been found in various fruits and vegetables and has diverse biological activities.{45217,45218,45219} It potentiates cytotoxicity and apoptosis induced by tumor necrosis factor-related apoptosis-induced ligand (TRAIL) in U87MG human glioma cells.{45217} In vivo, linarin potentiates TRAIL-induced tumor cell apoptosis and reduction of tumor growth in a U87MG mouse xenograft model. Linarin (12.5-50 mg/kg) reduces pulmonary platelet count, edema, and macrophage, polymorphonuclear leukocyte, and lymphocyte infiltration, as well as inhibits TXNIP/NLRP3, MAPK, and NF-κB signaling in a mouse model of LPS-induced acute lung injury.{45218} It also inhibits acetylcholinesterase (AChE) and induces dyskinesia recovery by 74.5 and 88%, respectively, in a zebrafish model of Alzheimer's disease when administered in tank water at a concentration of 50 μg/ml.{45219}