产品描述:
Omeprazole is an inhibitor of gastric H+/K+ ATPase (IC50 = 1.1 µM for the pig ATPase).{14045} It is a racemic mixture of esomeprazole (Item No. 17303) and (R)-omeprazole (Item No. 18874).{28643} Omeprazole (100 µM) decreases zymosan-induced oxygen free radical production in isolated human neutrophils.{51380} It is active against 17 strains of H. pylori (MIC50s = 12.5-50 µg/ml).{51382} It decreases histamine-induced acid secretion in dogs (ED50 = 0.35 µmol/kg).{51381} Formulations containing omeprazole have been used in the treatment of duodenal and gastric ulcers, gastroesophageal reflux disease, and erosive esophagitis.