产品描述:
Pixantrone-d8 is intended for use as an internal standard for the quantification of pixantrone (Item No. 20055) by GC- or LC-MS. Pixantrone is a DNA topoisomerase II inhibitor.{46348} It induces SV40 DNA cleavage in the presence of mouse topoisomerase II and induces DNA single-strand breaks in NCI H187 cells in a concentration-dependent manner. Pixantrone is cytotoxic to L1210 leukemia cells as well as doxorubicin-sensitive and -resistant LoVo colon adenocarcinoma cells (IC50 = 0.01, 0.24, and 7.2 µg/ml, respectively).{68058} It decreases disease severity in a rat model of myasthenia gravis induced by immunization with the T. californica acetylcholine receptor (AChR) when administered at a dose of 8.12 mg/kg once per week for six weeks.{68059} Formulations containing pixantrone have been used in the treatment of non-Hodgkin B cell lymphoma.