产品描述:
Pepstatin A is a bacteria-derived pentapeptide inhibitor of aspartic proteases.{62663,62664,62665} It inhibits pepsin, cathepsin D, and HIV protease (IC50s = 50s = 0.32 and 15 µM for the porcine and human enzymes, respectively).{62665} It inhibits HIV replication in infected H9 cells when used at a concentration of 100 µM and inhibits autophagy in PC12 cells.{62665,62666} Pepstatin A (10 and 50 mg/kg) decreases gastric acid levels and completely prevents pylorus ulceration in pylorus-ligated rats.{62663}