产品描述:
1-methyl-L-Tryptophan is an inhibitor of indoleamine 2,3-dioxygenase (IDO; Ki = 19 µM).{57592} It inhibits kynurenine production from primary human monocyte-derived IDO-positive dendritic cells and increases T cell proliferation in an allogeneic mixed lymphocyte reaction (allo-MLR) when used at a concentration of 100 µM. 1-methyl-L-Tryptophan reverses depressive-like behavior in mice in a Bacillus Calmette-Guerin inflammation-induced model of depression.{57593} Unlike 1-methyl-D-tryptophan, 1-methyl-L-tryptophan does not have an additive effect on survival induced by cyclophosphamide (Item No. 13849) in an orthotopic murine mammary carcinoma model of 4T1 tumors when administered at a dose of 400 mg/kg twice per day.{57592}