产品描述:
Aromadendrin is a flavone that has been found in J. chinensis and has diverse biological activities.{62033,62034,62035,62036} It scavenges DPPH (Item No. 14805) radicals (IC50 = 2.21 µM) and inhibits acetylcholinesterase (AChE; IC50 = 35.43 µM), but not butyrylcholinesterase (BChE) and β-secretase 1 (BACE1; IC50s = >200 µM), in cell-free assays.{62033,62034} Aromadendrin inhibits the growth of BT474 breast, ChaGo-K-1 lung, HepG2 liver, KATO III gastric, and SW620 colon cancer cells (IC50s = 11.66, 12.32, 13.67, 39.79, and 41.11 µM, respectively).{62033} It prevents cytokine production in anti-CD3 and anti-CD28-stimulated T cells in a concentration-dependent manner.{62035} Aromadendrin reduces pancreatic damage in a mouse model of caerulin and LPS-induced severe acute pancreatitis in a dose-dependent manner.{62036}