产品描述:
Exemestane is an irreversible inhibitor of aromatase (Ki = 26 nM).{64846} It is selective for aromatase over 5α-reductase when used at a concentration of 30 µM. Subcutaneous administration of exemestane (3-100 mg/kg per day) decreases tumor proliferation in rats with mammary tumors induced by the carcinogenic polycyclic aromatic hydrocarbon 7,12-dimethylbenz(a)anthracene (DMBA; Item No. 30383).{64847} Formulations containing exemestane have been used in the treatment of estrogen receptor-positive breast cancers in postmenopausal women.