产品描述:
PF-04981517 is a potent, time-dependent inhibitor of the cytochrome P450 (CYP450) isoform CYP3A4 (IC50 = 30 nM).{22614} It is less effective against CYP3A5 and CYP3A7 (IC50s = 17 and 70 μM, respectively).{22614} PF-04981517 will be useful for understanding the relative roles of CYP3A4 and CYP3A5 in drug metabolism.