产品描述:
Torcetrapib is an inhibitor of cholesteryl ester transfer protein (CETP; IC50s = 47 and 51 nM for cholesteryl and triglyceride transfer, respectively).{14626} It is selective for CETP over phospholipid transfer protein (PLTP), lecithin:cholesterol acyltransferase (LCAT), and hepatic and lipoprotein lipases at 10 µM. Torcetrapib (30 mg/kg) inhibits CETP activity and increases HDL cholesterol levels in serum from transgenic mice expressing human CETP and ApoA1.{41797} It increases mean arterial blood pressure in Zucker fa/fa diabetic rats when administered at doses of 60 and 200 mg/kg.