产品描述:
JSH-23 is an inhibitor of NF-κB, blocking its translocation into the nucleus (IC50 = 7.1 µM).{24719} It does not affect degradation of the inhibitor of NF-κB, IκB.{24719} JSH-23 interferes with NF-κB-mediated gene expression and apoptosis in RAW 264.7 cells treated with lipopolysaccharide.{24719} It has also been used to investigate the roles of NF-κB in cancer, inflammation, and neurogenesis.{24722,24720,24721}