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Quinacrine (hydrochloride hydrate)
品牌： Cayman
产品货号： 15041-100 mg
规格： 100 mg

报价：
折后价：

数量： - +
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  • 产品名称:
    Quinacrine (hydrochloride hydrate)
  • 别名:
    Atebrine|Mepacrine
  • 产品描述:
    Quinacrine is an acridine compound with diverse biological activities that has also been used as a stain for DNA and RNA in fixed cells and for fluorescent tracking of acidic vesicles, such as lysosomes, in live cells.{23969,23970,23759,23972} It has anti-protozoal properties, potently prevents misfolding of prion protein (EC50 = 0.3 μM), blocks voltage-dependent sodium channels (IC50 = 3.3 μM), and inhibits aldehyde oxidase (IC50 = 3.3 μM).{23969,23970,23759,23972} Quinacrine is also an effective riboflavin antagonist, associating with the riboflavin-binding protein (Ki = 6.7 μM), and an inhibitor of P-glycoprotein (EC50 = 14.4 μM).{23968,23971} At much higher doses, quinacrine inhibits phospholipase A2 activity.{23974,12506} Quinacrine binds to nucleic acids and has been used in fixed cells to stain DNA and RNA with excitation/emission maxima of 436/525 nm, respectively.{38900} In live cells, it is taken up into acidic vesicles, such as lysosomes, and can be used to for long-term imaging with an excitation of 458 nm and emission in the 470-580 nm range.{38901}
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  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    472.9
  • 产品形式:
    A crystalline solid
  • 存储溶液:
  • 有效期:
    1460
  • 产地:
    美国
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  • 纯度:
    ≥95%
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  • 分子式:
    C23H30ClN3O • 2HCl [XH2O]
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