产品描述:
Wiskott-Aldrich syndrome proteins (WASPs) regulate the actin cytoskeleton by directly interacting with actin in the Arp2/3 complex.{23890} As a result, they have essential functions in diverse cellular processes, including phagocytosis, cell motility, and membrane trafficking.{23889} Wiskostatin is a cell-permeable, selective inhibitor of neural WASP (N-WASP, IC50 = ~10 μM).{23889} It directly associates with the GTPase-binding domain of N-WASP, preventing its activation by Cdc42 and phosphatidylinositol 4,5-bisphosphate.{23889} By inhibiting N-WASP, wiskostatin interferes with membrane transport, endocytosis, and neurological development.{23891,23887,23888}